現(xiàn)貨moradec AH-207-DX說(shuō)明書(shū)
Fab-αHFc-CL-DX8951
Fab抗人IgG Fc-DX9851抗體
目錄號(hào)：AH-207-DX
Fab-αHFc-CL-DX8951是抗人IgG Fc特異性抗體的Fab片段，與甲磺酸艾替康（DX8951）結(jié)合，具有可裂解的接頭?？贵w部分是對(duì)人IgG的Fc區(qū)特異的多克隆抗體Fab片段。甲磺酸?？颂婵担―X8951）是一種拓?fù)洚悩?gòu)酶I抑制劑。連接DX8951和抗體的可裂解接頭（GGFG）在細(xì)胞外液中是穩(wěn)定的，但一旦綴合物通過(guò)內(nèi)吞作用進(jìn)入細(xì)胞，就會(huì)在內(nèi)體中被裂解。Fab 2°ADC的單價(jià)性質(zhì)在某些應(yīng)用中可能比全長(zhǎng)IgG 2°ADC具有一些優(yōu)勢(shì)。
| Fab Anti-Human IgG Fc-DX9851 Antibody with Cleavable Linker | Catalog Number: AH-207-DX |
| Fab-αHFc-CL-DX8951 is a Fab fragment of anti-human IgG Fc specific antibody conjugated to exatecan mesylate (DX8951) with a cleavable linker. The antibody portion is a polyclonal antibody Fab fragment specific to the Fc region of human IgGs. Exatecan mesylate (DX8951) is a topoisomerase I inhibitor. The cleavable linker (GGFG) connecting DX8951 to the antibody is stable in extracellular fluid, but is cleaved by in endosome once the conjugate has entered a cell via endocytosis.The mono-valence nature of Fab 2°ADC may have some advantage in certain applications than the full length IgG 2°ADC. | |
